Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a large-scale loss-of-function screen to identify genes that are required by KRAS-transformed colon ca...

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Detalhes bibliográficos
Main Authors: Steckel, Michael, Molina-Arcas, Miriam, Weigelt, Britta, Marani, Michaela, Warne, Patricia H, Kuznetsov, Hanna, Kelly, Gavin, Saunders, Becky, Howell, Michael, Downward, Julian, Hancock, David C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411175/
https://ncbi.nlm.nih.gov/pubmed/22613949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2012.82
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