Impairment of GABAB receptor dimer by endogenous 14-3-3ζ in chronic pain conditions

In the central nervous system, the inhibitory GABAB receptor is the archetype of heterodimeric G protein-coupled receptors (GPCRs). However, the regulation of GABAB dimerization, and more generally of GPCR oligomerization, remains largely unknown. We propose a novel mechanism for inhibition of GPCR...

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Detalhes bibliográficos
Main Authors: Laffray, Sophie, Bouali-Benazzouz, Rabia, Papon, Marie-Amélie, Favereaux, Alexandre, Jiang, Yang, Holm, Tina, Spriet, Corentin, Desbarats, Pascal, Fossat, Pascal, Le Feuvre, Yves, Decossas, Marion, Héliot, Laurent, Langel, Ulo, Nagy, Frédéric, Landry, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3411072/
https://ncbi.nlm.nih.gov/pubmed/22692127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.161
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