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PPAR agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein

Brown adipose tissue dissipates energy through heat and functions as a defense against cold and obesity. PPAR ligands have been shown to induce the browning of white adipocytes; however, the underlying mechanisms remain unclear. Here we show that PPAR ligands require full agonism to induce a brown f...

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Hlavní autoři: Ohno, Haruya, Shinoda, Kosaku, Spiegelman, Bruce M., Kajimura, Shingo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410936/
https://ncbi.nlm.nih.gov/pubmed/22405074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.01.019
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