6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

BACKGROUND: ATP-dependent D-alanine:D-alanine ligase (Ddl) is a part of biochemical machinery involved in peptidoglycan biosynthesis, as it catalyzes the formation of the terminal D-ala-D-ala dipeptide of the peptidoglycan precursor UDPMurNAc-pentapeptide. Inhibition of Ddl prevents bacterial growth...

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Main Authors: Škedelj, Veronika, Arsovska, Emilija, Tomašić, Tihomir, Kroflič, Ana, Hodnik, Vesna, Hrast, Martina, Bešter-Rogač, Marija, Anderluh, Gregor, Gobec, Stanislav, Bostock, Julieanne, Chopra, Ian, O'Neill, Alex J., Randall, Christopher, Zega, Anamarija
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410885/
https://ncbi.nlm.nih.gov/pubmed/22876277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039922
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