Loss of fused in sarcoma (FUS) promotes pathological Tau splicing

A subset of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) patients present pathological redistribution and aggregation of the nuclear protein fused in sarcoma (FUS) in the cytoplasm. Although FUS associates with the spliceosomal complex, no endogenous neuronal spli...

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Sonraí Bibleagrafaíochta
Main Authors: Orozco, Denise, Tahirovic, Sabina, Rentzsch, Kristin, Schwenk, Benjamin M, Haass, Christian, Edbauer, Dieter
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2012
Ábhair:
Scientific Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410390/
https://ncbi.nlm.nih.gov/pubmed/22710833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.90
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