Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin II to angiotensin-(1–7) and is expressed in podocytes. Here we overexpressed ACE2 in podocytes in experimental diabetic nephropathy using transgenic methods where a nephrin promoter drove the expression of human ACE2. Glomeruli from these m...

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Bibliographic Details
Main Authors: Nadarajah, Renisha, Milagres, Rosangela, Dilauro, Marc, Gutsol, Alex, Xiao, Fengxia, Zimpelmann, Joseph, Kennedy, Chris, Wysocki, Jan, Batlle, Daniel, Burns, Kevin D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410252/
https://ncbi.nlm.nih.gov/pubmed/22475818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2012.83
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