Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice

Angiotensin-converting enzyme 2 (ACE2) degrades angiotensin II to angiotensin-(1–7) and is expressed in podocytes. Here we overexpressed ACE2 in podocytes in experimental diabetic nephropathy using transgenic methods where a nephrin promoter drove the expression of human ACE2. Glomeruli from these m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nadarajah, Renisha, Milagres, Rosangela, Dilauro, Marc, Gutsol, Alex, Xiao, Fengxia, Zimpelmann, Joseph, Kennedy, Chris, Wysocki, Jan, Batlle, Daniel, Burns, Kevin D
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3410252/
https://ncbi.nlm.nih.gov/pubmed/22475818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2012.83
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados