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Novel Variants of Angiotensin Converting Enzyme-2 of Shorter Molecular Size to Target the Kidney Renin Angiotensin System

ACE2 is a monocarboxypeptidase which generates Angiotensin (1–7) from Angiotensin II (1–8). Attempts to target the kidney Renin Angiotensin System using native ACE2 to treat kidney disease are hampered by its large molecular size, 100 kDa, which precludes its glomerular filtration and subsequent tub...

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Detalhes bibliográficos
Publicado no:Biomolecules
Main Authors: Wysocki, Jan, Schulze, Arndt, Batlle, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995632/
https://ncbi.nlm.nih.gov/pubmed/31861139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom9120886
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