Kinetic evidence that echinomycin migrates between potential DNA binding sites.

The hypothesis that echinomycin locates its preferred nucleotide sequences in DNA by a process of "shuffling" between potential binding sites has been tested. Immediately after reacting with calf thymus DNA the antibiotic is relatively weakly bound inasmuch as the complex dissociates quite rapidly w...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Fox, K R, Waring, M J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1985
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC341017/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/4000928/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/13.2.595
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