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Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling

[Image: see text] A series of structurally simplified cryptocaryone analogues were synthesized by a facile Pd-catalyzed acetoxylation of alkyne-tethered cyclohexadienones and evaluated as inhibitors of NF-κB signaling. Compounds 10 and 11 were found to possess low micromolar inhibitory properties to...

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Autors principals: Hexum, Joseph K., Tello-Aburto, Rodolfo, Struntz, Nicholas B., Harned, Andrew M., Harki, Daniel A.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409840/
https://ncbi.nlm.nih.gov/pubmed/22866208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300034a
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