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Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells

We recently demonstrated that differentiation of cytotoxic T cells requires cooperation between T-cell receptor (TCR)/costimulation and γc-cytokines. Here we demonstrate that the transcription factor IFN regulatory factor 8 (IRF8) is expressed in CD8 T cells by the combination of these two signals....

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Detalhes bibliográficos
Main Authors: Miyagawa, Fumi, Zhang, Hong, Terunuma, Atshushi, Ozato, Keiko, Tagaya, Yutaka, Katz, Stephen I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409775/
https://ncbi.nlm.nih.gov/pubmed/22783014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201453109
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