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Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches
PURPOSE: The catalytic selectivity of human UGT1A9, an important membrane-bound enzyme catalyzing glucuronidation of xenobiotics were determined experimentally using 145 phenolics, and analyzed by 3D-QSAR methods. METHODS: The catalytic efficiency of UGT1A9 was determined by kinetic profiling. Quant...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3409642/ https://ncbi.nlm.nih.gov/pubmed/22302521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0666-z |
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