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Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

Glucuronidation is often recognized as one of the rate-determining factors that limit the bioavailability of flavonols. Hence, design and synthesis of more bioavailable flavonols would benefit from the establishment of predictive models of glucuronidation using kinetic parameters [e.g., K(m), V(max)...

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書誌詳細
主要な著者: Wu, Baojian, Morrow, John Kenneth, Singh, Rashim, Zhang, Shuxing, Hu, Ming
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3033718/
https://ncbi.nlm.nih.gov/pubmed/21068207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.175356
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