Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein

Two to three years after infection, a fraction of HIV-1–infected individuals develop serologic activity that neutralizes most viral isolates. Broadly neutralizing antibodies that recognize the HIV-1 envelope protein have been isolated from these patients by single-cell sorting and by neutralization...

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Detalhes bibliográficos
Main Authors: Klein, Florian, Gaebler, Christian, Mouquet, Hugo, Sather, D. Noah, Lehmann, Clara, Scheid, Johannes F., Kraft, Zane, Liu, Yan, Pietzsch, John, Hurley, Arlene, Poignard, Pascal, Feizi, Ten, Morris, Lynn, Walker, Bruce D., Fätkenheuer, Gerd, Seaman, Michael S., Stamatatos, Leonidas, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409500/
https://ncbi.nlm.nih.gov/pubmed/22826297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20120423
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