A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations

To develop a comprehensive overview of copy number aberrations (CNAs) in stage-II/III colorectal cancer (CRC), we characterized 302 tumors from the PETACC-3 clinical trial. Microsatellite-stable (MSS) samples (n = 269) had 66 minimal common CNA regions, with frequent gains on 20 q (72.5%), 7 (41.8%)...

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Bibliografische gegevens
Hoofdauteurs: Xie, Tao, d’ Ario, Giovanni, Lamb, John R., Martin, Eric, Wang, Kai, Tejpar, Sabine, Delorenzi, Mauro, Bosman, Fred T., Roth, Arnaud D., Yan, Pu, Bougel, Stephanie, Di Narzo, Antonio Fabio, Popovici, Vlad, Budinská, Eva, Mao, Mao, Weinrich, Scott L., Rejto, Paul A., Hodgson, J. Graeme
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409212/
https://ncbi.nlm.nih.gov/pubmed/22860045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042001
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