A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations

To develop a comprehensive overview of copy number aberrations (CNAs) in stage-II/III colorectal cancer (CRC), we characterized 302 tumors from the PETACC-3 clinical trial. Microsatellite-stable (MSS) samples (n = 269) had 66 minimal common CNA regions, with frequent gains on 20 q (72.5%), 7 (41.8%)...

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Detalhes bibliográficos
Main Authors: Xie, Tao, d’ Ario, Giovanni, Lamb, John R., Martin, Eric, Wang, Kai, Tejpar, Sabine, Delorenzi, Mauro, Bosman, Fred T., Roth, Arnaud D., Yan, Pu, Bougel, Stephanie, Di Narzo, Antonio Fabio, Popovici, Vlad, Budinská, Eva, Mao, Mao, Weinrich, Scott L., Rejto, Paul A., Hodgson, J. Graeme
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409212/
https://ncbi.nlm.nih.gov/pubmed/22860045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042001
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