Unique Alterations of an Ultraconserved Non-Coding Element in the 3′UTR of ZIC2 in Holoprosencephaly

Coding region alterations of ZIC2 are the second most common type of mutation in holoprosencephaly (HPE). Here we use several complementary bioinformatic approaches to identify ultraconserved cis-regulatory sequences potentially driving the expression of human ZIC2. We demonstrate that an 804 bp ele...

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Détails bibliographiques
Auteurs principaux: Roessler, Erich, Hu, Ping, Hong, Sung-Kook, Srivastava, Kshitij, Carrington, Blake, Sood, Raman, Petrykowska, Hanna, Elnitski, Laura, Ribeiro, Lucilene A., Richieri-Costa, Antonio, Feldman, Benjamin, Odenwald, Ward F., Muenke, Maximilian
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409191/
https://ncbi.nlm.nih.gov/pubmed/22859937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039026
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