Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

BACKGROUND: The striato-nigral projecting pathway contains the highest concentrations of dynorphin in the brain. The functional role of this opioid peptide in the regulation of mesencephalic dopaminergic (DAergic) neurons is not clear. We reported previously that exogenous dynorphin exerts potent ne...

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Detalhes bibliográficos
Main Authors: Wang, Qingshan, Shin, Eun-Joo, Nguyen, Xuan-Khanh Thi, Li, Quan, Bach, Jae-Hyung, Bing, Guoying, Kim, Won-Ki, Kim, Hyoung-Chun, Hong, Jau-Shyong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409049/
https://ncbi.nlm.nih.gov/pubmed/22695044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-124
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