Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor

BACKGROUND: We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Dang, Duy-Khanh, Shin, Eun-Joo, Kim, Dae-Joong, Tran, Hai-Quyen, Jeong, Ji Hoon, Jang, Choon-Gon, Nah, Seung-Yeol, Jeong, Jung Hwan, Byun, Jae Kyung, Ko, Sung Kwon, Bing, Guoying, Hong, Jau-Shyong, Kim, Hyoung-Chun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5822489/
https://ncbi.nlm.nih.gov/pubmed/29467000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1087-7
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