Combination of HDAC and topoisomerase inhibitors in small cell lung cancer

Histone deacetylase (HDAC) inhibitors, including MGCD0103 and vorinostat, have led to tumor growth inhibition and apoptosis in vivo. However, with limited single-agent activity demonstrated in solid tumor trials, we examined the potential for enhanced effects in combination with topoisomerase I and...

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Main Authors: Gray, Jhanelle, Cubitt, Christopher L., Zhang, Shumin, Chiappori, Alberto
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408970/
https://ncbi.nlm.nih.gov/pubmed/22441819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.19848
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