Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo

The P140K point mutant of MGMT allows robust hematopoietic stem cell (HSC) enrichment in vivo. Thus, dual-gene vectors that couple MGMT and therapeutic gene expression have allowed enrichment of gene-corrected HSCs in animal models. However, expression levels from dual-gene vectors are often reduced...

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Main Authors: Roth, Justin C., Ismail, Mourad, Reese, Jane S., Lingas, Karen T., Ferrari, Giuliana, Gerson, Stanton L.
Format: Artigo
Jezik:Inglês
Izdano: International Scholarly Research Network 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408655/
https://ncbi.nlm.nih.gov/pubmed/22888445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5402/2012/212586
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