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Update on the Phenotypic Spectrum of Lesch-Nyhan Disease and its Attenuated Variants

Congenital deficiency of the enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a spectrum of clinical phenotypes. All of these phenotypes are associated with marked overproduction of uric acid and related problems such as hyperuricemia, urate nephrolithiasis, tophi, and gout. T...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Torres, Rosa J., Puig, Juan G., Jinnah, Hyder A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408650/
https://ncbi.nlm.nih.gov/pubmed/22198833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11926-011-0231-5
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