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Mutation hotspots in yeast caused by long-range clustering of homopolymeric sequences

Evolutionary theory assumes that mutations occur randomly in the genome; however, studies performed in a variety of organisms indicate the existence of context-dependent mutation biases. Sources of mutagenesis variation across large genomic contexts (e.g. hundreds of bases) have not been identified....

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Detalhes bibliográficos
Main Authors: Ma, Xin, Rogacheva, Maria V., Nishant, K. T., Zanders, Sarah, Bustamante, Carlos D., Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408629/
https://ncbi.nlm.nih.gov/pubmed/22832106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2011.10.003
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