Detection of Heterozygous Mutations in the Genome of Mismatch Repair Defective Diploid Yeast Using a Bayesian Approach

DNA replication errors that escape polymerase proofreading and mismatch repair (MMR) can lead to base substitution and frameshift mutations. Such mutations can disrupt gene function, reduce fitness, and promote diseases such as cancer and are also the raw material of molecular evolution. To analyze...

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Main Authors: Zanders, Sarah, Ma, Xin, RoyChoudhury, Arindam, Hernandez, Ryan D., Demogines, Ann, Barker, Brandon, Gu, Zhenglong, Bustamante, Carlos D., Alani, Eric
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2010
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954485/
https://ncbi.nlm.nih.gov/pubmed/20660644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.120105
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