Detection of Heterozygous Mutations in the Genome of Mismatch Repair Defective Diploid Yeast Using a Bayesian Approach

DNA replication errors that escape polymerase proofreading and mismatch repair (MMR) can lead to base substitution and frameshift mutations. Such mutations can disrupt gene function, reduce fitness, and promote diseases such as cancer and are also the raw material of molecular evolution. To analyze...

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Bibliografiske detaljer
Main Authors: Zanders, Sarah, Ma, Xin, RoyChoudhury, Arindam, Hernandez, Ryan D., Demogines, Ann, Barker, Brandon, Gu, Zhenglong, Bustamante, Carlos D., Alani, Eric
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2010
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Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954485/
https://ncbi.nlm.nih.gov/pubmed/20660644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.120105
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