Detection of Heterozygous Mutations in the Genome of Mismatch Repair Defective Diploid Yeast Using a Bayesian Approach

DNA replication errors that escape polymerase proofreading and mismatch repair (MMR) can lead to base substitution and frameshift mutations. Such mutations can disrupt gene function, reduce fitness, and promote diseases such as cancer and are also the raw material of molecular evolution. To analyze...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zanders, Sarah, Ma, Xin, RoyChoudhury, Arindam, Hernandez, Ryan D., Demogines, Ann, Barker, Brandon, Gu, Zhenglong, Bustamante, Carlos D., Alani, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2010
Schlagworte:
Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954485/
https://ncbi.nlm.nih.gov/pubmed/20660644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.110.120105
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge