Restoration of Hearing in the VGLUT3 Knockout Mouse Using Virally-Mediated Gene Therapy

Mice lacking the vesicular glutamate transporter-3 (VGLUT3) are congenitally deaf due to loss of glutamate release at the inner hair cell afferent synapse. Cochlear delivery of VGLUT3 using adeno-associated virus-1 (AAV1) leads to transgene expression in only inner hair cells (IHC), despite broader...

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Main Authors: Akil, Omar, Seal, Rebecca P., Burke, Kevin, Wang, Chuansong, Alemi, Aurash, During, Matthew, Edwards, Robert H., Lustig, Lawrence R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408581/
https://ncbi.nlm.nih.gov/pubmed/22841313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.05.019
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