A Dual Role for Receptor-interacting Protein Kinase 2 (RIP2) Kinase Activity in Nucleotide-binding Oligomerization Domain 2 (NOD2)-dependent Autophagy

Autophagy is triggered by the intracellular bacterial sensor NOD2 (nucleotide-binding, oligomerization domain 2) as an anti-bacterial response. Defects in autophagy have been implicated in Crohn's disease susceptibility. The molecular mechanisms of activation and regulation of this process by N...

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Main Authors: Homer, Craig R., Kabi, Amrita, Marina-García, Noemí, Sreekumar, Arun, Nesvizhskii, Alexey I., Nickerson, Kourtney P., Chinnaiyan, Arul M., Nuñez, Gabriel, McDonald, Christine
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408141/
https://ncbi.nlm.nih.gov/pubmed/22665475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.326835
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