The Nucleotide Synthesis Enzyme CAD Inhibits NOD2 Antibacterial Function in Human Intestinal Epithelial Cells

BACKGROUND & AIMS: Polymorphisms that reduce the function of nucleotide-binding oligomerization domain (NOD)2, a bacterial sensor, have been associated with Crohn’s disease (CD). No proteins that regulate NOD2 activity have been identified as selective pharmacologic targets. We sought to discove...

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Detalhes bibliográficos
Main Authors: Richmond, Amy L., Kabi, Amrita, Homer, Craig R., García, Noemí Marina, Nickerson, Kourtney P., NesvizhskiI, Alexey I., Sreekumar, Arun, Chinnaiyan, Arul M., Nuñez, Gabriel, McDonald, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565430/
https://ncbi.nlm.nih.gov/pubmed/22387394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.02.040
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