The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer

BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it is unclear how it promotes tumourigenesis. We report that re-expression of BRG1 in lung cancer cells up-regulates lung-specific transcripts, restoring the gene expression signature of normal lung. Using cell lines from several cance...

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Main Authors: Romero, Octavio A, Setien, Fernando, John, Sam, Gimenez-Xavier, Pol, Gómez-López, Gonzalo, Pisano, David, Condom, Enric, Villanueva, Alberto, Hager, Gordon L, Sanchez-Cespedes, Montse
Formato: Artigo
Idioma:Inglês
Publicado: WILEY-VCH Verlag 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407948/
https://ncbi.nlm.nih.gov/pubmed/22407764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200236
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