Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

Overcoming the resistance of tumours to chemotherapy, often due to downregulation of Bax and Bak, represents a significant clinical challenge. It is therefore important to identify novel apoptosis inducers that bypass Bax and Bak. Potassium channels are emerging as oncological targets and a crucial...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Leanza, Luigi, Henry, Brian, Sassi, Nicola, Zoratti, Mario, Chandy, K George, Gulbins, Erich, Szabò, Ildikò
Format: Artigo
Sprache:Inglês
Veröffentlicht: WILEY-VCH Verlag 2012
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407946/
https://ncbi.nlm.nih.gov/pubmed/22496117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200235
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