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PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium

BACKGROUND: Planar Cell Polarity (PCP) signaling is a key regulator of epithelial morphogenesis, including neural tube closure and the orientation of inner ear sensory hair cells, and is mediated by a conserved noncanonical Wnt pathway. Ptk7 is a novel vertebrate-specific regulator of PCP, yet the m...

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Detalhes bibliográficos
Main Authors: Lee, Jianyi, Andreeva, Anna, Sipe, Conor W., Liu, Lixia, Cheng, Amy, Lu, Xiaowei
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407606/
https://ncbi.nlm.nih.gov/pubmed/22560610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2012.03.068
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