Glutaminase Dysregulation in HIV-1-Infected Human Microglia Mediates Neurotoxicity: Relevant to HIV-1-Associated Neurocognitive Disorders

Microglia represent the main cellular targets of HIV-1 in the brain. Infected and/or activated microglia play a pathogenic role in HIV-associated neurocognitive disorders (HAND) by instigating primary dysfunction and subsequent death of neurons. Although microglia are known to secrete neurotoxins wh...

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Autori principali: Huang, Yunlong, Zhao, Lixia, Jia, Beibei, Wu, Li, Li, Yuju, Curthoys, Norman, Zheng, Jialin C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2011
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407550/
https://ncbi.nlm.nih.gov/pubmed/22016553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2051-11.2011
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