NF-κB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors

BACKGROUND: Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell tumors has not been established. Also unclear is the molecular mechanism that drives th...

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Detalhes bibliográficos
Main Authors: McCarthy, Brian A, Yang, Liqun, Ding, Jane, Ren, Mingqiang, King, William, ElSalanty, Mohammed, Zakhary, Ibrahim, Sharawy, Mohamed, Cui, Hongjuan, Ding, Han-Fei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407530/
https://ncbi.nlm.nih.gov/pubmed/22642622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-203
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