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Influence of Mabs on PrP(Sc) Formation Using In Vitro and Cell-Free Systems

PrP(Sc) is believed to serve as a template for the conversion of PrP(C) to the abnormal isoform. This process requires contact between the two proteins and implies that there may be critical contact sites that are important for conversion. We hypothesized that antibodies binding to either PrP(c)or P...

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Autors principals: Chang, Binggong, Petersen, Robert, Wisniewski, Thomas, Rubenstein, Richard
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407222/
https://ncbi.nlm.nih.gov/pubmed/22848548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041626
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