Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif

Hsp90 is an essential chaperone that is necessary for the folding, stability and activity of numerous proteins. In this study, we demonstrate that free radicals formed during oxidative stress conditions can cleave Hsp90. This cleavage occurs through a Fenton reaction which requires the presence of r...

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Detalhes bibliográficos
Main Authors: Beck, Raphaël, Dejeans, Nicolas, Glorieux, Christophe, Creton, Mélanie, Delaive, Edouard, Dieu, Marc, Raes, Martine, Levêque, Philippe, Gallez, Bernard, Depuydt, Matthieu, Collet, Jean-François, Calderon, Pedro Buc, Verrax, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407180/
https://ncbi.nlm.nih.gov/pubmed/22848402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040795
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