The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90

Tetratricopeptide (TPR) domains are known protein interaction domains. We show that the TPR domain of FKBP8 selectively binds Hsp90, and interactions upstream of the conserved MEEVD motif are critical for tight binding. In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essenti...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Blundell, Katie L. I. M., Pal, Mohinder, Roe, S. Mark, Pearl, Laurence H., Prodromou, Chrisostomos
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344419/
https://ncbi.nlm.nih.gov/pubmed/28278223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173543
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