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The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90
Tetratricopeptide (TPR) domains are known protein interaction domains. We show that the TPR domain of FKBP8 selectively binds Hsp90, and interactions upstream of the conserved MEEVD motif are critical for tight binding. In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essenti...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5344419/ https://ncbi.nlm.nih.gov/pubmed/28278223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173543 |
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