Hsp90 Is Cleaved by Reactive Oxygen Species at a Highly Conserved N-Terminal Amino Acid Motif

Hsp90 is an essential chaperone that is necessary for the folding, stability and activity of numerous proteins. In this study, we demonstrate that free radicals formed during oxidative stress conditions can cleave Hsp90. This cleavage occurs through a Fenton reaction which requires the presence of r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Beck, Raphaël, Dejeans, Nicolas, Glorieux, Christophe, Creton, Mélanie, Delaive, Edouard, Dieu, Marc, Raes, Martine, Levêque, Philippe, Gallez, Bernard, Depuydt, Matthieu, Collet, Jean-François, Calderon, Pedro Buc, Verrax, Julien
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407180/
https://ncbi.nlm.nih.gov/pubmed/22848402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040795
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge