Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

Staphylococcal enterotoxin B (SEB) exposure triggers an exaggerated pro-inflammatory cytokine response that often leads to toxic shock syndrome (TSS) associated with organ failure and death. MyD88 mediates pro-inflammatory cytokine signaling induced by SEB exposure and MyD88(−/−) mice are resistant...

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Autors principals: Kissner, Teri L., Ruthel, Gordon, Alam, Shahabuddin, Mann, Enrique, Ajami, Dariush, Rebek, Mitra, Larkin, Eileen, Fernandez, Stefan, Ulrich, Robert G., Ping, Sun, Waugh, David S., Rebek, Julius, Saikh, Kamal U.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407147/
https://ncbi.nlm.nih.gov/pubmed/22848400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040773
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