A Small Molecule That Mimics the BB-loop in the Toll Interleukin-1 (IL-1) Receptor Domain of MyD88 Attenuates Staphylococcal Enterotoxin B-induced Pro-inflammatory Cytokine Production and Toxicity in Mice

Toxic shock syndrome (TSS) is a clinical consequence of the profound amplification of host pro-inflammatory cytokine signaling that results from staphylococcal enterotoxin (SE) exposure. We recently reported that MyD88(−/−) mice were resistant to SEA or SEB toxic shock and displayed reduced levels o...

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Detalhes bibliográficos
Main Authors: Kissner, Teri L., Moisan, Lionel, Mann, Enrique, Alam, Shahabuddin, Ruthel, Gordon, Ulrich, Robert G., Rebek, Mitra, Rebek, Julius, Saikh, Kamal U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173059/
https://ncbi.nlm.nih.gov/pubmed/21693701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.204982
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