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Influence of GABA(A) Receptor α Subunit Isoforms on the Benzodiazepine Binding Site

Classical benzodiazepines, such as diazepam, interact with α(x)β(2)γ(2) GABA(A) receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different receptor isoforms probably results in selective behavioural effects as sedation and anxiolysis. Knowledge of differences in the structure of...

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Hlavní autoři: Lüscher, Benjamin P., Baur, Roland, Goeldner, Maurice, Sigel, Erwin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407089/
https://ncbi.nlm.nih.gov/pubmed/22848717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042101
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