Hepatitis B Virus X Protein Upregulates mTOR Signaling through IKKβ to Increase Cell Proliferation and VEGF Production in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC), a major cause of cancer-related death in Southeast Asia, is frequently associated with hepatitis B virus (HBV) infection. HBV X protein (HBx), encoded by a viral non-structural gene, is a multifunctional regulator in HBV-associated tumor development. We investigated n...

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Autores principales: Yen, Chia-Jui, Lin, Yih-Jyh, Yen, Chia-Sheng, Tsai, Hung-Wen, Tsai, Ting-Fen, Chang, Kwang-Yu, Huang, Wei-Chien, Lin, Pin-Wen, Chiang, Chi-Wu, Chang, Ting-Tsung
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407061/
https://ncbi.nlm.nih.gov/pubmed/22848663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041931
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