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Milnacipran inhibits glutamatergic N-Methyl-D-Aspartate receptor activity in Spinal Dorsal Horn Neurons

BACKGROUND: Antidepressants, which are widely used for treatment of chronic pain, are thought to have antinociceptive effects by blockade of serotonin and noradrenaline reuptake. However, these drugs also interact with various receptors such as excitatory glutamatergic receptors. Thermal hyperalgesi...

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Détails bibliographiques
Auteurs principaux: Kohno, Tatsuro, Kimura, Masafumi, Sasaki, Mika, Obata, Hideaki, Amaya, Fumimasa, Saito, Shigeru
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407012/
https://ncbi.nlm.nih.gov/pubmed/22716121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-8-45
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