Neurosteroid dehydroepiandrosterone sulphate enhances pain transmission in rat spinal cord dorsal horn

BACKGROUND: The neurosteroid dehydroepiandrosterone sulphate (DHEAS) activates the sigma-1 receptor, inhibits gamma-aminobutyric acid A (GABA(A)) and glycine receptors, and induces hyperalgesic effects. Although its effects have been studied in various tissues of the nervous system, its synaptic mec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Anaesth
Prif Awduron: Yamamoto, Goh, Kamiya, Yoshinori, Sasaki, Mika, Ikoma, Miho, Baba, Hiroshi, Kohno, Tatsuro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier 2019
Pynciau:
Pain Mechanisms and Novel Analgesic
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6676051/
https://ncbi.nlm.nih.gov/pubmed/31030988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2019.03.026
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