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Structural basis of TLR5-flagellin recognition and signaling
Toll-like receptor 5 (TLR5) binding to bacterial flagellin activates NF-κB signaling and triggers an innate immune response to the invading pathogen. To elucidate the structural basis and mechanistic implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5, a...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406927/ https://ncbi.nlm.nih.gov/pubmed/22344444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1215584 |
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