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Crown ether–electrolyte interactions permit nanopore detection of individual DNA abasic sites in single molecules
DNA abasic (AP) sites are one of the most frequent lesions in the genome and have a high mutagenic potential if unrepaired. After selective attachment of 2-aminomethyl-18-crown-6 (18c6), individual AP lesions are detected during electrophoretic translocation through the bacterial protein ion channel...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406832/ https://ncbi.nlm.nih.gov/pubmed/22711805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201669109 |
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