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Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway

The role of the polymorphism Met or Val in position 129 in the human prion protein is well documented regarding disease susceptibility and clinical manifestations. However, little is known about the molecular background to this phenomenon. We investigated herein the conformational stability, amyloid...

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Main Authors: Nyström, Sofie, Mishra, Rajesh, Hornemann, Simone, Aguzzi, Adriano, Nilsson, K. Peter R., Hammarström, Per
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406681/
https://ncbi.nlm.nih.gov/pubmed/22669942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372136
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