Multiple Substitutions of Methionine 129 in Human Prion Protein Reveal Its Importance in the Amyloid Fibrillation Pathway

The role of the polymorphism Met or Val in position 129 in the human prion protein is well documented regarding disease susceptibility and clinical manifestations. However, little is known about the molecular background to this phenomenon. We investigated herein the conformational stability, amyloid...

Full description

Saved in:
Bibliographic Details
Main Authors: Nyström, Sofie, Mishra, Rajesh, Hornemann, Simone, Aguzzi, Adriano, Nilsson, K. Peter R., Hammarström, Per
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406681/
https://ncbi.nlm.nih.gov/pubmed/22669942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.372136
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items