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Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

Circadian clocks in mammals are based on a negative feedback loop in which transcriptional repression by the cryptochromes, CRY1 and CRY2, lies at the heart of the mechanism. Despite similarities in sequence, domain structure, and biochemical activity, they play distinct roles in clock function. How...

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Détails bibliographiques
Auteurs principaux: Khan, Sanjoy K., Xu, Haiyan, Ukai-Tadenuma, Maki, Burton, Brittany, Wang, Yongmei, Ueda, Hiroki R., Liu, Andrew C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406676/
https://ncbi.nlm.nih.gov/pubmed/22692217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.368001
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