Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells

Exploiting protein homeostasis is a new therapeutic approach in cancer. Nelfinavir (NFV) is an HIV protease inhibitor that induces endoplasmic reticulum (ER) stress in cancer cells. Under conditions of ER stress, misfolded proteins are transported from the ER back to the cytosol for subsequent degra...

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Bibliografiske detaljer
Main Authors: Kawabata, S, Gills, J J, Mercado-Matos, J R, LoPiccolo, J, Wilson, W, Hollander, M C, Dennis, P A
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406586/
https://ncbi.nlm.nih.gov/pubmed/22825471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.87
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