Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine

Anticancer phospholipids that inhibit Akt such as the alkylphospholipid perifosine (Per) and phosphatidylinositol ether lipid analogs (PIAs) promote cellular detachment and apoptosis and have a similar cytotoxicity profile against cancer cell lines in the NCI60 panel. While investigating the mechani...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gills, J J, Zhang, C, Abu-Asab, M S, Castillo, S S, Marceau, C, LoPiccolo, J, Kozikowski, A P, Tsokos, M, Goldkorn, T, Dennis, P A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2012
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406576/
https://ncbi.nlm.nih.gov/pubmed/22764099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.72
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